杨亚军博士在Int J Mol Sci杂志发表论文阐述了一种酸性药物在内外实验中对EV71病毒体活性的影响

2013年5月3日，医科院动研所卫生部人类疾病比较医学中心的杨亚军博士发表了题目为“Chebulagic Acid, a Hydrolyzable Tannin, Exhibited Antiviral Activity in Vitro and in Vivo against Human Enterovirus 71”，报告了人EV71病毒体内体外实验中，一种酸性药物对病毒活性的影响。通讯作者为张连峰教授。

全文网址：http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676802/pdf/ijms-14-09618.pdf

英文摘要：

Int J Mol Sci. 2013 May 3;14(5):9618-27. doi: 10.3390/ijms14059618.

Chebulagic Acid, a Hydrolyzable Tannin, Exhibited Antiviral Activity in Vitro and in Vivo against Human Enterovirus 71.

Yang Y, Xiu J, Liu J, Zhang L, Li X, Xu Y, Qin C, Zhang L.

Source

Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, PUMC, Beijing 100021, China. zhanglf@cnilas.org.

Abstract

Human enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. Presently, no vaccines or antiviral drugs have been clinically available to employ against EV71. In this study, we demonstrate that treatment with chebulagic acid reduced the viral cytopathic effect on rhabdomyosarcoma cells with an IC50 of 12.5 μg/mL. The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to efficiently reduce mortality and relieve clinical symptoms through the inhibition of viral replication. Chebulagic acid may represent a potential therapeutic agent to control infections to enterovirus 71.