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Int J Mol Sci-Chebulagic Acid, a Hydrolyzable Tannin, Exhibited Antiviral Activity in Vitro and in Vivo against Human Enterovirus 71

2013年10月11日 来源:

      2013年5月3日,医科院动研所卫生部人类疾病比较医学中心的杨亚军博士发表了题目为“Chebulagic Acid, a Hydrolyzable Tannin, Exhibited Antiviral Activity in Vitro and in Vivo against Human Enterovirus 71”,报告了人EV71病毒体内体外实验中,一种酸性药物对病毒活性的影响。

      Int J Mol Sci. 2013 May 3;14(5):9618-27. doi: 10.3390/ijms14059618.

      Chebulagic Acid, a Hydrolyzable Tannin, Exhibited Antiviral Activity in Vitro and in Vivo against Human Enterovirus 71.

      Yang Y, Xiu J, Liu J, Zhang L, Li X, Xu Y, Qin C, Zhang L.


Source

      Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, PUMC, Beijing 100021, China. zhanglf@cnilas.org.


Abstract


      Human enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. Presently, no vaccines or antiviral drugs have been clinically available to employ against EV71. In this study, we demonstrate that treatment with chebulagic acid reduced the viral cytopathic effect on rhabdomyosarcoma cells with an IC50 of 12.5 μg/mL. The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to efficiently reduce mortality and relieve clinical symptoms through the inhibition of viral replication. Chebulagic acid may represent a potential therapeutic agent to control infections to enterovirus 71.

全文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676802/