郭建国课题组
背景介绍：
人类的工业化进程加剧了环境的污染，其中空气污染导致心血管疾病、中风、慢阻肺等疾病的上升。室内环境作为人生活的主要场所同时收到室内污染、室外污染和居民三者的共同作用。研究室内环境对提高人生活品质有重要意义。室内环境中的化学污染物种类随着工业的发展成指数增长，而关于室内环境污染下，微生物的进化规律却研究滞后，我们将专注于主要挥发性污染物与微生物的关系，并利用线虫、无菌动物建立评价室内微生物环境的方法。此外，我们利用多种动物模型对于主要的空气污染物PM2.5的生物危害和机制进行挖掘。随着我国深空探测工程的进行，如何在外太空环境中保证宇航员的健康是一个关键问题。我们课题组利用三维随机定位回旋仪模拟微重力效应，通过不同的动物模型来研究失重环境下的生理变化及其机制（心血管功能失调、肌肉萎缩、失重性骨质流失、免疫功能下降、航天贫血症和空间运动病等）；宇宙辐射对健康的危害（肿瘤发生、白内障等）；长期幽闭环境对心理的影响（空间乘员心理相容性、环境心理适应性等）等。
研究方向：
1）人居室环境中化学污染物与微生物的互作及其潜在的健康风险；
2）PM2.5污染对呼吸系统疾病发生和发展的影响；
3）利用不同动物模型对太空环境长期驻留的健康危害进行评价和干预。
1）人居室环境中化学污染物与微生物的互作及其潜在的健康风险；
2）PM2.5污染对呼吸系统疾病发生和发展的影响；
3）利用不同动物模型对太空环境长期驻留的健康危害进行评价和干预。
组成成员：
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| 郭建国 助理研究员 |
康台生 技师 |
研究成果：
1）承担科研项目情况：
1.国家自然科学基金委员会，面上项目，82070103，利用小鼠模型探索不同空气菌群类型对肺炎发病过程的影响机制，2021-01～2024-12，55万，在研，主持
2.中国医学科学院，医学与健康科技创新工程，2018-I2M-1-001，表型组基础与转化研究，2018-01～2021-01，150万，在研，子课题负责人
3.国家科技部，国家重点研发计划，2017YFC0702800，室内微生物污染源头识别监测和综合控制技术，2017-10～ 2021-04，24万元，在研，子课题负责人
4.国家财政部，中央级公益性科研院所基本科研业务费，2016ZX310037，冬季重雾霾污染条件下卧室内微生物群落的演变，2016-01～2016-12，8万元，结题，主持
5.国家科技部，国家科技支撑计划，2010BAC68B02，典型河口污染水域生态修复技术与示范，2010-05～2013-05，720万，已结题，参加
6.国家自然科学基金委员会，青年科学基金，21207012，硫丹诱导miR-22表达变化与人内皮细胞损伤和功能失调的关联，2013-01～2015-12，25万，已结题，参加
7.大连市科学技术局，应急项目，2011E11SF007，大连海域石油污染监测与生态评估关键技术集成与示范，2011-01～2012-12，100万，已结题，参加
2.中国医学科学院，医学与健康科技创新工程，2018-I2M-1-001，表型组基础与转化研究，2018-01～2021-01，150万，在研，子课题负责人
3.国家科技部，国家重点研发计划，2017YFC0702800，室内微生物污染源头识别监测和综合控制技术，2017-10～ 2021-04，24万元，在研，子课题负责人
4.国家财政部，中央级公益性科研院所基本科研业务费，2016ZX310037，冬季重雾霾污染条件下卧室内微生物群落的演变，2016-01～2016-12，8万元，结题，主持
5.国家科技部，国家科技支撑计划，2010BAC68B02，典型河口污染水域生态修复技术与示范，2010-05～2013-05，720万，已结题，参加
6.国家自然科学基金委员会，青年科学基金，21207012，硫丹诱导miR-22表达变化与人内皮细胞损伤和功能失调的关联，2013-01～2015-12，25万，已结题，参加
7.大连市科学技术局，应急项目，2011E11SF007，大连海域石油污染监测与生态评估关键技术集成与示范，2011-01～2012-12，100万，已结题，参加
2）代表论著：
1.Guo, J.; Xiong, Y.; Shi, C.; Liu, C.; Li, H.; Qian, H.; Sun, Z.; Qin, C., Characteristics of airborne bacterial communities in indoor and outdoor environments during continuous haze events in Beijing: Implications for health care. Environment International 2020, 139, 105721.
2.Guo, J.; Kong, Q.; Liu, C.; Kang, T.; Qin, C., Evaluating the health risks of pneumonia from airborne bacterial communities using 16S rDNA sequences of pneumonia-related pathogens. Biomedical and Environmental Sciences 2020.
3.Guo, J.; Tang, J.; Kang, T.; Xiong, Y.; Xiang, Z.; Qin, C., Different immunization methods lead to altered gut flora and varied responses to Mycobacterium tuberculosis infection in mice. Journal of infection in developing countries 2020, 14, (10), 1170-1177.
4.Guo, J.; Xiong, Y.; Kang, T.; Xiang, Z.; Qin, C., Bacterial community analysis of floor dust and HEPA filters in air purifiers used in office rooms in ILAS, Beijing. Sci Rep-Uk 2020, 10, (1), 6417.
5.Guo, J.; Sun, Y.; Mi, D.; Qin, C., Differential Responses of Bacterial Communities Inhabiting Pristine and Industrially Polluted Sediment from Oil Spills along Dalian, China. Journal of Coastal Research 2019, 36, (2), 218-227.
6.Guo, J.; Zhao, L.; Lu, W.; Jia, H.; Sun, Y., Bacterial communities in water and sediment shaped by paper mill pollution and indicated bacterial taxa in sediment in Daling River. Ecological Indicators 2016, 60, 766-773.
7.Guo, J.; Zhao, L.; Lu, W.; Jia, H.; Wang, L.; Liu, X.; Sun, Y., Effect of historical residual hexachlorocyclohexanes and dichlorodiphenyltrichloroethane on bacterial communities in sediment core collected from an estuary in northeastern China by next-generation sequencing. Mar Pollut Bull 2015, 93, (1-2), 68-74.
8.郭建国; 赵龙浩; 徐丹; 孙野青, 洪水对大凌河河流浮游细菌群落的影响. 生态学报 2015, 35, (14), 4777-4783.
9.郭建国; 孙野青, 造纸工业污染源对周边土壤细菌群落的影响. 大连海事大学学报 2015, 41, (04), 127-132.
10.郭建国; 赵龙浩; 徐丹; 孙野青, 人工湿地处理造纸废水后细菌群落结构变化. 生态学报 2014, 34, (08), 2095-2101.
11.郭建国; 卢卫红; 孙野青, recql4基因的结构及其蛋白功能的研究进展. 药物生物技术 2009, 16, (03), 279-282+286.
12.Kong, Q.; Xiang, Z.; Wu, Y.; Gu, Y.; Guo, J.; Geng, F., Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection. Molecular cancer 2020, 19, (1), 80.
13.Guo, K.; Qian, H.; Zhao, D.; Ye, J.; Zhang, Y.; Kan, H.; Zhao, Z.; Deng, F.; Huang, C.; Zhao, B.; Zeng, X.; Sun, Y.; Liu, W.; Mo, J.; Sun, C.; Guo, J.; Zheng, X., Indoor exposure levels of bacteria and fungi in residences, schools, and offices in China: A systematic review. Indoor air 2020, 30, (6), 1147-1165.
14.Xiang, Z.; Zhu, H.; Yang, B.; Fan, H.; Guo, J.; Liu, J.; Kong, Q.; Teng, Q.; Shang, H.; Su, L.; Qin, C., A glance at the gut microbiota of five experimental animal species through fecal samples. Sci Rep 2020, 10, (1), 16628.
15.Su, L.; Zhu, H.; Niu, Y.; Guo, Y.; Du, X.; Guo, J.; Zhang, L.; Qin, C., Phylogeny and taxonomic revision of Kernia and Acaulium. Sci Rep 2020, 10, (1), 10302.
16.Xiang, Z.; Tong, W.; Guo, Z.; Xu, Y.; Guo, J.; Ruan, Y.; Zhao, P., Rat H1 parvovirus infection leads to alterations in gut microbiota. Pathogens and Disease 2019, 77, (5).
17.Su, L.; Zhu, H.; Guo, Y.; Du, X.; Guo, J.; Zhang, L.; Qin, C., Lecanicillium coprophilum (Cordycipitaceae, Hypocreales), a new species of fungus from the feces of Marmota monax in China. Phytotaxa 2019, 387, (1), 55-62.
18.Song, N.; Zhang, L.; Chen, W.; Zhu, H.; Deng, W.; Han, Y.; Guo, J.; Qin, C., Cyanidin 3-O-beta-glucopyranoside activates peroxisome proliferator-activated receptor-gamma and alleviates cognitive impairment in the APP(swe)/PS1(DeltaE9) mouse model. Biochimica et biophysica acta 2016, 1862, (9), 1786-800.
19.Li, S.; Xu, D.; Guo, J.; Sun, Y., Inhibition of cell growth and induction of inflammation by endosulfan in HUVEC-C cells. Environmental toxicology 2016, 31, (12), 1785-1795.
20.Liu, X.; Jia, H.; Wang, L.; Qi, H.; Ma, W.; Hong, W.; Guo, J.; Yang, M.; Sun, Y.; Li, Y. F., Characterization of polycyclic aromatic hydrocarbons in concurrently monitored surface seawater and sediment along Dalian coast after oil spill. Ecotoxicol Environ Saf 2013, 90, 151-6.
21.Shi, J..; Guo, J..; Li, W.; Zhang, M.; Huang, L.; Sun, Y., Cytogenetic effects of low doses of energetic carbon ions on rice after exposures of dry seeds, wet seeds and seedlings. J Radiat Res 2010, 51, (3), 235-42.
22.徐丹; 郭建国; 孙野青 In 硫丹对人脐静脉内皮细胞的生物学效应分析, 持久性有机污染物论坛2012暨第七届持久性有机污染物全国学术研讨会, 中国天津, 2012; 中国天津, 2012; pp 300-301.
23.王荦; 刘宪杰; 郭建国; 杨萌; 洪文俊; 贾宏亮; 孙野青; 李一凡, 辽宁省大凌河口水体中有机氯农药的污染特征. 海洋环境科学 2013, 32, (03), 410-413.
2.Guo, J.; Kong, Q.; Liu, C.; Kang, T.; Qin, C., Evaluating the health risks of pneumonia from airborne bacterial communities using 16S rDNA sequences of pneumonia-related pathogens. Biomedical and Environmental Sciences 2020.
3.Guo, J.; Tang, J.; Kang, T.; Xiong, Y.; Xiang, Z.; Qin, C., Different immunization methods lead to altered gut flora and varied responses to Mycobacterium tuberculosis infection in mice. Journal of infection in developing countries 2020, 14, (10), 1170-1177.
4.Guo, J.; Xiong, Y.; Kang, T.; Xiang, Z.; Qin, C., Bacterial community analysis of floor dust and HEPA filters in air purifiers used in office rooms in ILAS, Beijing. Sci Rep-Uk 2020, 10, (1), 6417.
5.Guo, J.; Sun, Y.; Mi, D.; Qin, C., Differential Responses of Bacterial Communities Inhabiting Pristine and Industrially Polluted Sediment from Oil Spills along Dalian, China. Journal of Coastal Research 2019, 36, (2), 218-227.
6.Guo, J.; Zhao, L.; Lu, W.; Jia, H.; Sun, Y., Bacterial communities in water and sediment shaped by paper mill pollution and indicated bacterial taxa in sediment in Daling River. Ecological Indicators 2016, 60, 766-773.
7.Guo, J.; Zhao, L.; Lu, W.; Jia, H.; Wang, L.; Liu, X.; Sun, Y., Effect of historical residual hexachlorocyclohexanes and dichlorodiphenyltrichloroethane on bacterial communities in sediment core collected from an estuary in northeastern China by next-generation sequencing. Mar Pollut Bull 2015, 93, (1-2), 68-74.
8.郭建国; 赵龙浩; 徐丹; 孙野青, 洪水对大凌河河流浮游细菌群落的影响. 生态学报 2015, 35, (14), 4777-4783.
9.郭建国; 孙野青, 造纸工业污染源对周边土壤细菌群落的影响. 大连海事大学学报 2015, 41, (04), 127-132.
10.郭建国; 赵龙浩; 徐丹; 孙野青, 人工湿地处理造纸废水后细菌群落结构变化. 生态学报 2014, 34, (08), 2095-2101.
11.郭建国; 卢卫红; 孙野青, recql4基因的结构及其蛋白功能的研究进展. 药物生物技术 2009, 16, (03), 279-282+286.
12.Kong, Q.; Xiang, Z.; Wu, Y.; Gu, Y.; Guo, J.; Geng, F., Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection. Molecular cancer 2020, 19, (1), 80.
13.Guo, K.; Qian, H.; Zhao, D.; Ye, J.; Zhang, Y.; Kan, H.; Zhao, Z.; Deng, F.; Huang, C.; Zhao, B.; Zeng, X.; Sun, Y.; Liu, W.; Mo, J.; Sun, C.; Guo, J.; Zheng, X., Indoor exposure levels of bacteria and fungi in residences, schools, and offices in China: A systematic review. Indoor air 2020, 30, (6), 1147-1165.
14.Xiang, Z.; Zhu, H.; Yang, B.; Fan, H.; Guo, J.; Liu, J.; Kong, Q.; Teng, Q.; Shang, H.; Su, L.; Qin, C., A glance at the gut microbiota of five experimental animal species through fecal samples. Sci Rep 2020, 10, (1), 16628.
15.Su, L.; Zhu, H.; Niu, Y.; Guo, Y.; Du, X.; Guo, J.; Zhang, L.; Qin, C., Phylogeny and taxonomic revision of Kernia and Acaulium. Sci Rep 2020, 10, (1), 10302.
16.Xiang, Z.; Tong, W.; Guo, Z.; Xu, Y.; Guo, J.; Ruan, Y.; Zhao, P., Rat H1 parvovirus infection leads to alterations in gut microbiota. Pathogens and Disease 2019, 77, (5).
17.Su, L.; Zhu, H.; Guo, Y.; Du, X.; Guo, J.; Zhang, L.; Qin, C., Lecanicillium coprophilum (Cordycipitaceae, Hypocreales), a new species of fungus from the feces of Marmota monax in China. Phytotaxa 2019, 387, (1), 55-62.
18.Song, N.; Zhang, L.; Chen, W.; Zhu, H.; Deng, W.; Han, Y.; Guo, J.; Qin, C., Cyanidin 3-O-beta-glucopyranoside activates peroxisome proliferator-activated receptor-gamma and alleviates cognitive impairment in the APP(swe)/PS1(DeltaE9) mouse model. Biochimica et biophysica acta 2016, 1862, (9), 1786-800.
19.Li, S.; Xu, D.; Guo, J.; Sun, Y., Inhibition of cell growth and induction of inflammation by endosulfan in HUVEC-C cells. Environmental toxicology 2016, 31, (12), 1785-1795.
20.Liu, X.; Jia, H.; Wang, L.; Qi, H.; Ma, W.; Hong, W.; Guo, J.; Yang, M.; Sun, Y.; Li, Y. F., Characterization of polycyclic aromatic hydrocarbons in concurrently monitored surface seawater and sediment along Dalian coast after oil spill. Ecotoxicol Environ Saf 2013, 90, 151-6.
21.Shi, J..; Guo, J..; Li, W.; Zhang, M.; Huang, L.; Sun, Y., Cytogenetic effects of low doses of energetic carbon ions on rice after exposures of dry seeds, wet seeds and seedlings. J Radiat Res 2010, 51, (3), 235-42.
22.徐丹; 郭建国; 孙野青 In 硫丹对人脐静脉内皮细胞的生物学效应分析, 持久性有机污染物论坛2012暨第七届持久性有机污染物全国学术研讨会, 中国天津, 2012; 中国天津, 2012; pp 300-301.
23.王荦; 刘宪杰; 郭建国; 杨萌; 洪文俊; 贾宏亮; 孙野青; 李一凡, 辽宁省大凌河口水体中有机氯农药的污染特征. 海洋环境科学 2013, 32, (03), 410-413.
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