品系编号：ILAS-002-S-000051

品系名称：SD-Tg(Npy)400Mcwi大鼠

英文名称：SD-Tg(Npy)400Mcwi rat

其它名称：

物种描述：转基因

传代：

外观特征：毛色：。

遗传特征：染色体为21对?

品系来源：14.5 kb lambda clone of the rat Npy gene was subcloned with a polylinker that had NotI and EcoRI restriction sites. This transgene that was released by NotI digestion contained ~5kb 5'and ~1kb 3' and was injected into the pronuclei of fertilized SD rats. Founders were mated with SD females. F1 animals were mated with SD females till line 400 hemizygous animals were developed that had 5 copies of the Npy gene.

相关亚系：

生物学特征：大鼠繁殖快。肠道较短，盲肠较大，但盲肠功能不发达。性情较凶猛、抗病力强。无胆囊。不能呕吐。不耐饥饿，肠内能合成维生素C。双子宫。胸部和鼠蹊部各有三对乳头。胰腺十分分散，位于胃和十二指肠弯曲处。

寿命与疾病：寿命3～4年。

研究应用：生物医学研究。

饲养与繁殖：大鼠2月龄时性成熟，性周期4天左右，妊娠期20（19～22），哺乳期21天，每天产仔平均8只，为全年、多发情性动物。?

保种单位：Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin

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