PLoS Pathogens: Long-Term Control of Powerful HIV Fusion Inhibitors for Viral Replication in AIDS Macaques

In February 2019,He Yuxian team, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, and Qinchuan team, the Institute of Laboratory Animal Sciences of the Chinese Academy of Medical Sciences published online in the journal PloS Pathogens.  They found that by a single low dose (3 mg/kg) of LP - 80 treatment, HIV/AIDS in rhesus monkeys viral load quickly fell to testing lines, and two times a week monotherapy can suppress the virus for a long time (6 months). Lp-80 is the most effective HIV fusion inhibitor and is expected to be applied in clinical practice. The original title of the article is “Monotherapy with a low-dose lipopeptide HIV fusion inhibitor maintains long-term viral suppression in rhesus macaques.

Figure LP-80 treatment of chronic infection in rhesus monkeys in SHIV

Zhong Huihui,an associate researcher at the Institute of Pathogen Biology of the Chinese Academy of Medical Sciences, Xue Jing, an associate researcher at the Institute of Laboratory Animal Sciences of the Chinese Academy of Medical Sciences and Zhu Yunajiang, at the Institute of Pathogen Biology of the Chinese Academy of Medical Sciences are the lead authors of the paper. The project was supported by the National Natural Science Foundation of China (81630061,81473255), the Major Infectious Disease Special Project (2018ZX10301103) and the Innovation Project of the Chinese Academy of Medical Sciences (2017-I2M-1-014).