Skin Diseases Research Group

Overview:

Skin Diseases Research Group of the Center for Comparative Medicine was established in 2012. The Skin Diseases Research Group mainly uses skin and hair follicles as the model system, and applies genetic engineering, pathological staining and cell biology techniques to study the mechanism of signaling pathway system's involvement in epithelial development, microenvironmental balance and cancer.

Research Direction:

Development of skin hair follicle, microenvironmental balance, and cancer-related signaling mechanisms.

Staff  Composition:

Group leader: Chen Jiang, associate professor, researcher

Group member: Liang Wei

Contact Information：010-67761551

Scientific Research Achievements:

In this study, shRNA therapy research using gene mutant knock-in mice as animal models showed that modification of mutant phenotypes using nucleic acid interference yielded long-lasting results, providing an experimental reference for clinical treatment of genetic disorders related to skin and hair. The mouse and rat models of skin disease-related gene knock-in were constructed to study the key role of key genes in the development of hair follicles and skin.

　　1.Liu Y, Snedecor ER, Zhang X, et al. Correction of hair shaft defects through Allele-Specific silencing of mutant Krt75[J]. J Invest Dermatol, 2016 Jan;136(1):45-51.

　　2.Liu Y, Snedecor ER, Choi YJ, et al. Gorab is required for dermal condensate cells to respond to hedgehog signals during hair follicle morphogenesis. J Invest Dermatol, 2016 Feb;136(2):378-86.