Environment and Health Research Group
Background:
The process of human industrialization aggravated environmental pollution, among which air pollution led to the rise of cardiovascular disease, stroke, chronic obstructive pulmonary disease and other diseases. Indoor environment, as the main place of people, is affected by indoor pollution, outdoor pollution and residents. It is of great significance to study indoor environment to improve people's quality of life. The types of chemical pollutants in indoor environment increase exponentially with the development of industry, while the study on the evolution of microorganisms, under indoor environmental pollution is lag behind . We will focus on the relationship between major volatile pollutants and microorganisms, and use nematodes and sterile animals to establish methods for the evaluation of indoor microbial environment. In addition, we used a variety of animal models to explore the biological hazards and mechanisms of the major air pollutant PM2.5. With the development of China's deep space exploration project, how to ensure the health of astronauts in the outer space environment is a key problem. Our research group simulate microgravity effects with three-dimensional random positioning cyclotron, and study physiological changes and their mechanisms (cardiovascular dysfunction, muscle atrophy, weightless bone loss, decreased immune function, aerospace anemia, space motion disease, etc.) under weightless environment through different animal models. We also carry out research on health hazards from cosmic radiation (tumorigenesis, cataracts, etc., and effects of long-term claustrophobic environment on psychology (psychological compatibility of space crew, psychological adaptability of environment, etc.), etc.
Research direction:
1) Interactions between chemical pollutants and microorganisms in indoor environment and their potential health risks;
2) The impact of PM2.5 pollution on the occurrence and development of respiratory diseases;
3) Use different animal models to evaluate and intervene the long-term health hazards of space environment.
Staff Composition:
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Guo Jianguo |
Kang Taisheng |
Scientific research projects:
2.Chinese Academy of Medical Sciences, Science and Technology Innovation Project for Medicine and Health, 2018-I2M-1-001, Basic and Translational Research of Phenotype group, 2018-01 ~ 2021-01, 1.5 million, in research, sub-project leader
3.National Key Research and Development Plan of the Ministry of Science and Technology, 2017YFC0702800, Monitoring and Comprehensive Control Technology of Indoor Microbial Pollution Source Identification, 2017-10~2021-04, 240,000 Yuan, in research, charger of sub-project
4.Basic scientific research operating expenses of public welfare research institutes at the central level, Ministry of Finance, 2016ZX310037, Evolution of Microbial Community in Bedroom Under Heavy Haze Pollution in Winter, 2016-01~2016-12, 8,000 Yuan, conclusion, presided the project
5.National Science and Technology Support Plan, Ministry of Science and Technology, 2010BAC68B02, Ecological Restoration Technology and Demonstration of Typical Estuarine Polluted Waters, 2010-05~2013-05, 7.2 million, concluded, participated the project.
6.National Natural Science Foundation of China, Science Foundation for Youth, 21207012, Association Between Endosulfan Induced miR-22 Expression Changes and Human Endothelial Cell Injury and Dysfunction, 2013/01~2015/12, 250,000, concluded , participated in this project
7.Dalian Science and Technology Bureau, Emergency Project, 2011E11SF007, Integration and Demonstration of Key Technologies for Monitoring and Ecological Assessment of Petroleum Pollution in Dalian Sea Area, 2011-01~ 2012-12, one million, concluded, participated in this project
2.Guo, J.; Kong, Q.; Liu, C.; Kang, T.; Qin, C., Evaluating the health risks of pneumonia from airborne bacterial communities using 16S rDNA sequences of pneumonia-related pathogens. Biomedical and Environmental Sciences 2020.
3.Guo, J.; Tang, J.; Kang, T.; Xiong, Y.; Xiang, Z.; Qin, C., Different immunization methods lead to altered gut flora and varied responses to Mycobacterium tuberculosis infection in mice. Journal of infection in developing countries 2020, 14, (10), 1170-1177.
4.Guo, J.; Xiong, Y.; Kang, T.; Xiang, Z.; Qin, C., Bacterial community analysis of floor dust and HEPA filters in air purifiers used in office rooms in ILAS, Beijing. Sci Rep-Uk 2020, 10, (1), 6417.
5.Guo, J.; Sun, Y.; Mi, D.; Qin, C., Differential Responses of Bacterial Communities Inhabiting Pristine and Industrially Polluted Sediment from Oil Spills along Dalian, China. Journal of Coastal Research 2019, 36, (2), 218-227.
6.Guo, J.; Zhao, L.; Lu, W.; Jia, H.; Sun, Y., Bacterial communities in water and sediment shaped by paper mill pollution and indicated bacterial taxa in sediment in Daling River. Ecological Indicators 2016, 60, 766-773.
7.Guo, J.; Zhao, L.; Lu, W.; Jia, H.; Wang, L.; Liu, X.; Sun, Y., Effect of historical residual hexachlorocyclohexanes and dichlorodiphenyltrichloroethane on bacterial communities in sediment core collected from an estuary in northeastern China by next-generation sequencing. Mar Pollut Bull 2015, 93, (1-2), 68-74.
8.郭建国; 赵龙浩; 徐丹; 孙野青, 洪水对大凌河河流浮游细菌群落的影响. 生态学报 2015, 35, (14), 4777-4783.
9.郭建国; 孙野青, 造纸工业污染源对周边土壤细菌群落的影响. 大连海事大学学报 2015, 41, (04), 127-132.
10.郭建国; 赵龙浩; 徐丹; 孙野青, 人工湿地处理造纸废水后细菌群落结构变化. 生态学报 2014, 34, (08), 2095-2101.
11.郭建国; 卢卫红; 孙野青, recql4基因的结构及其蛋白功能的研究进展. 药物生物技术 2009, 16, (03), 279-282+286.
12.Kong, Q.; Xiang, Z.; Wu, Y.; Gu, Y.; Guo, J.; Geng, F., Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection. Molecular cancer 2020, 19, (1), 80.
13.Guo, K.; Qian, H.; Zhao, D.; Ye, J.; Zhang, Y.; Kan, H.; Zhao, Z.; Deng, F.; Huang, C.; Zhao, B.; Zeng, X.; Sun, Y.; Liu, W.; Mo, J.; Sun, C.; Guo, J.; Zheng, X., Indoor exposure levels of bacteria and fungi in residences, schools, and offices in China: A systematic review. Indoor air 2020, 30, (6), 1147-1165.
14.Xiang, Z.; Zhu, H.; Yang, B.; Fan, H.; Guo, J.; Liu, J.; Kong, Q.; Teng, Q.; Shang, H.; Su, L.; Qin, C., A glance at the gut microbiota of five experimental animal species through fecal samples. Sci Rep 2020, 10, (1), 16628.
15.Su, L.; Zhu, H.; Niu, Y.; Guo, Y.; Du, X.; Guo, J.; Zhang, L.; Qin, C., Phylogeny and taxonomic revision of Kernia and Acaulium. Sci Rep 2020, 10, (1), 10302.
16.Xiang, Z.; Tong, W.; Guo, Z.; Xu, Y.; Guo, J.; Ruan, Y.; Zhao, P., Rat H1 parvovirus infection leads to alterations in gut microbiota. Pathogens and Disease 2019, 77, (5).
17.Su, L.; Zhu, H.; Guo, Y.; Du, X.; Guo, J.; Zhang, L.; Qin, C., Lecanicillium coprophilum (Cordycipitaceae, Hypocreales), a new species of fungus from the feces of Marmota monax in China. Phytotaxa 2019, 387, (1), 55-62.
18.Song, N.; Zhang, L.; Chen, W.; Zhu, H.; Deng, W.; Han, Y.; Guo, J.; Qin, C., Cyanidin 3-O-beta-glucopyranoside activates peroxisome proliferator-activated receptor-gamma and alleviates cognitive impairment in the APP(swe)/PS1(DeltaE9) mouse model. Biochimica et biophysica acta 2016, 1862, (9), 1786-800.
19.Li, S.; Xu, D.; Guo, J.; Sun, Y., Inhibition of cell growth and induction of inflammation by endosulfan in HUVEC-C cells. Environmental toxicology 2016, 31, (12), 1785-1795.
20.Liu, X.; Jia, H.; Wang, L.; Qi, H.; Ma, W.; Hong, W.; Guo, J.; Yang, M.; Sun, Y.; Li, Y. F., Characterization of polycyclic aromatic hydrocarbons in concurrently monitored surface seawater and sediment along Dalian coast after oil spill. Ecotoxicol Environ Saf 2013, 90, 151-6.
21.Shi, J..; Guo, J..; Li, W.; Zhang, M.; Huang, L.; Sun, Y., Cytogenetic effects of low doses of energetic carbon ions on rice after exposures of dry seeds, wet seeds and seedlings. J Radiat Res 2010, 51, (3), 235-42.
22.徐丹; 郭建国; 孙野青 In 硫丹对人脐静脉内皮细胞的生物学效应分析, 持久性有机污染物论坛2012暨第七届持久性有机污染物全国学术研讨会, 中国天津, 2012; 中国天津, 2012; pp 300-301.
23.王荦; 刘宪杰; 郭建国; 杨萌; 洪文俊; 贾宏亮; 孙野青; 李一凡, 辽宁省大凌河口水体中有机氯农药的污染特征. 海洋环境科学 2013, 32, (03), 410-413.
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