Environment and Health Research Group
The process of human industrialization aggravated environmental pollution, among which air pollution led to the rise of cardiovascular disease, stroke, chronic obstructive pulmonary disease and other diseases. Indoor environment, as the main place of people's life, is affected by indoor pollution, outdoor pollution and residents. It is of great significance to study indoor environment to improve people's quality of life. The types of chemical pollutants in indoor environment increase exponentially with the development of industry, while the study on the evolution of microorganisms, under indoor environmental pollution is left behind . We will focus on the relationship between major volatile pollutants and microorganisms, and use nematodes and sterile animals to establish methods for the evaluation of indoor microbial environment. In addition, we used a variety of animal models to explore the biological hazards and mechanisms of the major air pollutant PM2.5. With the development of China's deep space exploration project, how to ensure the health of astronauts in the outer space environment is a key problem. Our research group simulate microgravity effects with three-dimensional random positioning cyclotron, and study physiological changes and their mechanisms (cardiovascular dysfunction, muscle atrophy, weightless bone loss, decreased immune function, aerospace anemia, space motion disease, etc.) under weightless environment through different animal models. We also carry out research on health hazards from cosmic radiation (tumorigenesis, cataracts, etc., and effects of long-term claustrophobic environment on psychology (psychological compatibility of space crew, psychological adaptability of environment, etc.), etc.
Rapid and accurate models for human disease studies
Researchers at the Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, are improving rapid and accurate model development for infectious and complex diseases.
Nature∣ Qin Chuan Team：Elucidation on the Pathogenicity of Novel Coronavirus by Using hACE2 transgenic mice and Establishment of the International First Animal Model of Novel Coronavirus
On May 7, 2020, Qin Chuan team, from the Institute of Laboratory Animal Sciences of the Chinese Academy of Medical Sciences, jointly cooperated with other teams from National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Institute of Pathogen Biology of the Chinese Academy of Medical Sciences, Medical Molecular Biology Research Institute of the Chinese Academy of Medical Sciences. They officially published a research paper in Nature: "The Pathogenicity of SARS - CoV - 2 hACE2 in Transgenic Mice".
澳大利亚墨尔本大学微生物和免疫学系的Lachlan Coin和Sebastian Duchene团队及合作者，提供了新冠病毒的第一个直接RNA序列，详细介绍了该冠状病毒亚基因组长度的mRNA结构，并描述了从共享数据中揭示的冠状病毒进化遗传学的各个方面。相关论文3月7日发布于预印本服务器bioRxiv（bioRxiv所有论文未经同行评议）。