龚佳男课题组

简介：

龚佳男课题组成立于2021年，实验室面积约100平方米，拥有倒置荧光显微镜、生物安全柜、细胞培养箱、分析天平、PCR仪、超声破碎仪、流式细胞仪等细胞与分子生物学常用设备。研究所平台提供激光共聚焦显微镜以及小动物PET/CT、7T小动物核磁共振（MRI）、小动物超声成像、小动物活体光学成像等最为先进的小动物专用高分辨率分子影像设备，能较好的满足肿瘤研究相关细胞、分子生物学、动物实验的需求。

研究方向：

1. 新型肿瘤疾病模型的创制，包括动物模型和类器官模型。

2. 利用肿瘤疾病模型开展肿瘤发病机理、寻找治疗新靶点以及肿瘤耐药等研究。

人员组成：

课题组现有工作人员4人。

龚佳男，课题组长

任淑月，主管技师	王超，技师	程俣，技师

科研成果：

1.Jia-Nan Gong^*#, Tirta M Djajawi, Donia M Moujalled, Giovanna Pomilio, Tiffany Khong, Li-Ping Zhang, Pasquale L Fedele, Michael S Low, Mary Ann Anderson, Christopher D Riffkin, Christine A White, Ping Lan, Guillaume Lessene, Marco J Herold, Andreas Strasser, Andrew Spencer, George Grigoriadis, Andrew H Wei, Mark F van Delft, Andrew W Roberts^# and David C Huang^#. Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro‑survival BCL2 proteins. Cell Death Differ. 2025

2.Zhang LP, Wei YM, Luo MJ, Ren SY, Zhan XW, Wang C, Li ZF, Zhu RM, Yan S, Cheng Y, Xu JL, Yang XJ, Du KL, Wang JQ, Zhang GN, Du DX, Gao R, Zhao DB, Gong JN^#. Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer. Cell Death Dis. 2025 Mar 12;16(1):170.

3.闫硕，李雪，王超，徐嘉莉，程俣，张丽萍，苏磊^#，龚佳男^#. 质子泵抑制剂泮托拉唑促进幽门螺旋杆菌SS1在小鼠胃内的定植.中国比较医学杂志,2025, 35(2).

4.Chao Wang, Guo-Min Xie, Li-Ping Zhang, Shuo Yan, Jia-Li Xu, Yun-Lin Han, Ming-Jie Luo, Jia-Nan Gong^#. High Engraftment and Metastatic Rates in Orthotopic Xenograft Models of Gastric Cancer via Direct Implantation of Tumor Cell Suspensions. Cancers (Basel).2024 Feb 12;16(4):759.

5.Wei Y, Zhang L, Wang C, Li Z, Luo M, Xie G, Yang X, Li M, Ren S, Zhao D^#, Gao R^#, Gong JN^#. Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer. Animal Model Exp Med. 2023 Jun;6(3):245-254.

6.Ming‑Jie Luo, Michelle Palmieri, Chris D Riffkin, Anuratha Sakthianandeswaren, Tirta Mario Djajawi, Yumiko Hirokawa, Victoria Shuttleworth, David H Segal, Christine A White, Duong Nhu, Guillaume Lessene, Margaret Lee, Peter Gibbs, David CS Huang#, Oliver M Sieber# and Jia-Nan Gong#. Define the susceptibility of colorectal cancers to BH3 mimetic compounds. Cell Death Disease. 2020 Sep;11(9):735.