龚佳男，女，准聘助理教授，博士生导师。2008年毕业于西北农林科技大学，获得理学学士学位，2013年毕业于中国医学科学院基础医学研究所/清华大学医学院获理学博士学位。随后在墨尔本大学生物医学系/The Walter and Eliza Hall Institute of Medical Research 医学研究所开展博士后科研训练，2019年底以高层次人才引进中国医学科学院医学实验动物研究所工作，并获聘中国医学科学院/北京协和医学院准聘助理教授，2021年聘任为研究员。

主要从事肿瘤发生发展及转移机理和抗癌药物耐药性研究，预期寻找新的抗癌靶点，为新抗癌药物研发和联合用药提供生物学依据。近年来在Nature、Cancer Discovery、Blood、Cell Death and Differentiation等期刊发表论文30余篇。

1.新型肿瘤疾病模型的创制，包括动物模型和类器官模型。

2.利用肿瘤疾病模型开展肿瘤发病机理、寻找治疗新靶点以及肿瘤耐药等研究。

2024/12-至今、Frontiers in Oncology，杂志编辑

2021/7至今、Animal Models and Experimental Medicine, 杂志编委

2021，北京市科技新星，北京市科委

2023-2026，国家自然科学基金青年项目

2021-2024, 北京市科技新星项目；

2021-2025年，中国医学科学院北京协和医学院准聘助理教授人才引进项目

*第一作者；#通讯作者

1.Jia-Nan Gong*#, Tirta M Djajawi, Donia M Moujalled, Giovanna Pomilio, Tiffany Khong, Li-Ping Zhang, Pasquale L Fedele, Michael S Low, Mary Ann Anderson, Christopher D Riffkin, Christine A White, Ping Lan, Guillaume Lessene, Marco J Herold, Andreas Strasser, Andrew Spencer, George Grigoriadis, Andrew H Wei, Mark F van Delft, Andrew W Roberts# and David C Huang#. Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro‑survival BCL2 proteins. Cell Death Differ. 2025

2.Zhang LP, Wei YM, Luo MJ, Ren SY, Zhan XW, Wang C, Li ZF, Zhu RM, Yan S, Cheng Y, Xu JL, Yang XJ, Du KL, Wang JQ, Zhang GN, Du DX, Gao R, Zhao DB, Gong JN#. Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer. Cell Death Dis. 2025 Mar 12;16(1):170.

3.Chao Wang, Guo-Min Xie, Li-Ping Zhang, Shuo Yan, Jia-Li Xu, Yun-Lin Han, Ming-Jie Luo, Jia-Nan Gong#. High Engraftment and Metastatic Rates in Orthotopic Xenograft Models of Gastric Cancer via Direct Implantation of Tumor Cell Suspensions. Cancers (Basel).2024 Feb 12;16(4):759.

4.Wei Y, Zhang L, Wang C, Li Z, Luo M, Xie G, Yang X, Li M, Ren S, Zhao D#, Gao R#, Gong JN#. Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer. Animal Model Exp Med. 2023 Jun;6(3):245-254.

5.Ming‑Jie Luo, Michelle Palmieri, Chris D Riffkin, Anuratha Sakthianandeswaren, Tirta Mario Djajawi, Yumiko Hirokawa, Victoria Shuttleworth, David H Segal, Christine A White, Duong Nhu, Guillaume Lessene, Margaret Lee, Peter Gibbs, David CS Huang#, Oliver M Sieber# and Jia-Nan Gong#. Define the susceptibility of colorectal cancers to BH3 mimetic compounds. Cell Death Disease. 2020 Sep;11(9):735.

6.Piers Blombery*, Mary Ann Anderson*, Jia-nan Gong*, Rachel Thijssen*, Richard W.Birkinshaw*, Ella Thompson, Charis E. Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E. Lew, Ian J. Majewski, Daniel H.D. Gray, David A. Westerman, Constantine S. Tam, John F. Seymour, Peter E. Czabotar, David C.S. Huang, Andrew W. Roberts. Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia. Cancer Discovery. 2019 Mar;9(3):342-353.

7.Jia-nan Gong*, Tiffany Khong, David Segal, Yuan Yao, Chris D. Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessene, Andrew Spencer, Marco J. Herold, Andrew W. Roberts, David C. S. Huang. Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1. Blood. 2016 Oct;128(14):1834-1844. (Cover story)

8.Gong JN*, Yu J*, Lin HS*, Zhang XH, Yin XL, Xiao Z, Wang F, Wang XS, Su R, Shen C, Zhao HL, Ma YN, Zhang JW. The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia. Cell Death Differ. 2014 Jan;21(1):100-12.

9.Jia-nan Gong*, Jianxiong Li*, Yi Wang*, Changzheng Liu*, Hongyan Jia, Chongliang Jiang, Yuxuan Wang, Min Luo, Hongmei Zhao, Lei Dong, Fang Wang, Junwu Zhang, Jia Yu. Characterization of microRNA-29 family expression and investigation of their mechanistic and therapeutic roles in gastric cancer. Carcinogenesis. 2014 Feb; 35(2):497-506.

10.Xiao-Shuang Wang*, Jia-Nan Gong*, Jia Yu, Fang Wang, Xin-Hua Zhang, Xiao-Lin Yin, Zhen-Qing Tan, Zi-Mian Luo, Gui-Hua Yang, Chao Shen, Jun-Wu Zhang. MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood 2012 119:4992 -5004.