傅瑶
姓名：傅瑶
职称/职务：助理教授 | 研究员
学科：细胞生物学
联系方式：j2023110001@pumc.edu.cn
导师风采链接：
- 简历介绍
- 研究领域
- 社会任职
- 获奖及荣誉
- 承担科研项目情况
- 代表论著
傅瑶，女，博士，研究员，助理教授，博士生导师。1991年7月生于安徽省。2014年在武汉大学获得学士学位，2019年在北京大学获整合生命科学专业博士学位。主要从事干细胞和细胞命运重编程研究。阐明了化学重编程诱导多潜能干细胞（chemically induced pluripotent stem cells，CiPSCs）过程的分子机理；建立了高效快速的小鼠CiPS诱导体系；首次实现了人体细胞化学重编程诱导CiPS细胞。重要代表性研究成果分别发表在Nature、Cell、Cell Stem Cell等期刊上。
研究主要集中在再生医学领域，围绕干细胞与细胞命运重编程方向探索（1）实验动物替代产品与技术研发；（2）细胞疗法治疗疾病的新可能性。主要研究内容包括：基于化学小分子诱导细胞重编程策略，开发大动物模型干细胞制备新技术；研究全能干细胞和早期胚胎发育体外模型的制备技术；研究细胞命运调控的新机制，探索疾病治疗的新靶点。
目前主要承担医学与健康科技创新工程重点项目1项、参与国家重点研发计划“干细胞研究与器官修复”重点专项1项。
１．Jingyang Guan#; Guan Wang#; Jinlin Wang#; Zhengyuan Zhang#; Yao Fu#; Lin Cheng#; Gaofan Meng#; Yulin Lyu#; Jialiang Zhu; Yanqin Li; Yanglu Wang; Shijia Liuyang; Bei Liu; Zirun Yang; Huanjing He; Xinxing Zhong; Qijing Chen; Xu Zhang; Shicheng Sun; Weifeng Lai; Yan Shi; Lulu Liu; Lipeng Wang; Cheng Li; Shichun Lu*; Hongkui Deng*; Chemical reprogramming of human somatic cells to pluripotent stem cells, Nature, 2022, 605(7909): 325-331
２．Ting Zhao#; Yao Fu#; Jialiang Zhu#; Yifang Liu#; Qian Zhang#; Zexuan Yi#; Shi Chen; Zhonggang Jiao; Xiaochan Xu; Junquan Xu; Shuguang Duo; Yun Bai; Chao Tang; Cheng Li*; Hongkui Deng*; SingleCell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming, Cell Stem Cell, 2018, 23(1): 31-45
３．Yang Zhao#*; Ting Zhao#; Jingyang Guan#; Xu Zhang#; Yao Fu#; Junqing Ye#; Jialiang Zhu; Gaofan Meng; Jian Ge; Susu Yang; Lin Cheng; Yaqin Du; Chaoran Zhao; Ting Wang; Linlin Su; Weifeng Yang; Hongkui Deng*; A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming, Cell, 2015, 163(7): 1678-1691
４．Yaqin Du#; Ting Wang#; Jun Xu; Chaoran Zhao; Haibo Li; Yao Fu; Yaxing Xu; Liangfu Xie; Jingru Zhao; Weifeng Yang; Ming Yin; Jinhua Wen*; Hongkui Deng*. Efficient derivation of extended pluripotent stem cells from NOD-scid Il2rg-/- mice. Protein Cell. 2019 Jan;10(1):31-42.
５．Shijia Liuyang#; Guan Wang#; Yanglu Wang#; Huanjing He#; Yulin Lyu#; Lin Cheng; Zhihan Yang; Jingyang Guan; Yao Fu; Jialiang Zhu; Xinxing Zhong; Shicheng Sun; Cheng Li; Jinlin Wang* and Hongkui Deng*. Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming. Cell Stem Cell. 2023 Apr 6;30(4):450-459.e9.
６．Guan Wang#; Yanglu Wang#; Yulin Lyu#; Huanjing He#; Shijia Liuyang#; Jinlin Wang; Shicheng Sun; Lin Cheng; Yao Fu; Jialiang Zhu; Xinxing Zhong; Zhihan Yang; Qijing Chen; Cheng Li*; Jingyang Guan* and Hongkui Deng*. Chemical-induced epigenome resetting for regeneration program activation in human cells. Cell Rep. 2023 Jun 27;42(6):112547.
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