GC00008

Accession No

GC00009

Strain Name

SD.Lepr(tm)-GC/ILAS

Status

Live

Gene/full name

Lepr / leptin receptor

Gene ID

24536

Background

Sprague Dawley

Type

Knockout

Donor

Lianfeng Zhang, Yuanwu, Dan Bao ,Feifei Guan,Zhang, Xu Zhang, Wei Chen

Disease & Phenotype

lipid metabolism，obesity, diabetes 

Construction Description

Genotyping Protocols

Lepr-S1：GTTTACTAGACACGGATTCAGCAC  

Lepr-AS1：AATGGAAACGCTTTGCTGAATG

Mating System

Heterozygote x Heterozygote;

Homozygote is infertile

Reference

1. 1.Dan Bao,Yuanwu Ma,Xu Zhang. Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System, Sci Rep. 2015; 5: 15942.