白琳课题组

组长：
白琳 副研究员
组员：
石桂英 副主任技师	黄艺滢 研究实习员	雷雪裴 助理研究员

　　科研成果：

　　（1）建立了实验动物及疾病动物模型干细胞库，用于临床药物筛选和疾病机制的研究。

　　（2）建立多种帕金森疾病动物模型及干细胞治疗帕金森动物模型有效性和安全性评价体系。

　　（3）利用基因修饰小鼠，研究衰老过程中干细胞的稳态维持和再生能力的改变以及机体衰老的机制。

　　承担项目：

　　课题组已承担完成多项研究项目，包括国家自然科学基金青年项目、北京市自然科学基金、教育部博士点新教师类基金、协和青年项目、中央级公益性科研院所基本科研业务费等。正在承担项目包括国家自然基金面上项目、北京市自然基金重点项目、中国医学科学院医学与健康科技创新工程项目。研究成果发表于Cell Research, Cell Death & Disease， Experimental Cell Research和Journal of Cellular Biochemistry等杂志。

　　发表文章列表：

　　1.Lin Bai*, Guiying Shi, Yuanwu Ma, Li Zhang, Feifei Guan, Xu Zhang, Yanfeng Xu, Houzao Chen and Lianfeng Zhang: Paraoxonase 1 knockout rats have impaired T cell development at the CD4/CD8 double-negative to double-positive transition stage. Scientific Reports 8: 14457 (2018)

　　2.Li Q*, Bai L*, Shi G, Zhang L, Dai Y, Liu P, Cong YS, Wang M: Ptrf transgenic mice exhibit obesity and fatty liver. Clinical and experimental pharmacology & physiology 2018.

　　3.Ma Y*, Yu L, Zhang X, Xin C, Huang S, Bai L, Chen W, Gao R, Li J, Pan S, Qi X, Huang X, Zhang L: Highly efficient and precise base editing by engineered dCas9-guide tRNA adenosine deaminase in rats. Cell Discov, 2018 Jul 17.

　　4.Ma Y*, Yu L, Pan S, Gao S, Chen W, Zhang X, Dong W, Li J, Zhou R, Huang L, Han Y, Bai L, Zhang L, Zhang L. CRISPR/Cas9-mediated targeting of the Rosa26 locus produces Cre reporter rat strains for monitoring Cre-loxP-mediated lineage tracing. FEBS J. 2017 Oct;284(19):3262-3277.

　　5.Bai L*, Shi G, Yang Y, Chen W, Zhang L: Anti-Aging Effect of Siraitia grosuenoriiby Enhancement of Hematopoietic Stem Cell Function. Am J Chin Med 2016:1-13.

　　6.Bai L*, Shi G, Zhang L, Guan F, Ma Y, Li Q, Cong YS, Zhang L: Cav-1 deletion impaired hematopoietic stem cell function. Cell Death Dis 2014, 5:e1140.

　　7.Ma Y*, Zhang X, Shen B, Lu Y, Chen W, Ma J, Bai L, Huang X, Zhang L: Generating rats with conditional alleles using CRISPR/Cas9. Cell Res 2014, 24(1):122-125.

　　8.Li Q*, Bai L*, Liu N, Wang M, Liu JP, Liu P, Cong YS: Increased polymerase I and transcript release factor (Cavin-1) expression attenuates platelet-derived growth factor receptor signalling in senescent human fibroblasts. Clin Exp Pharmacol Physiol 2014, 41(3):169-173.

　　9.Yang Y*, Ma J, Xiu J, Bai L, Guan F, Zhang L, Liu J: Deferoxamine compensates for decreases in B cell counts and reduces mortality in enterovirus 71-infected mice. Mar Drugs 2014, 12(7):4086-4095.

　　10.Ma Y*, Ma J, Zhang X, Chen W, Yu L, Lu Y, Bai L, Shen B, Huang X, Zhang L: Generation of eGFP and Cre knockin rats by CRISPR/Cas9. FEBS J 2014, 281(17):3779-3790.

　　11.Bai L*, Shi G, Zhang X, Dong W, Zhang L: Transgenic expression of BRCA1 disturbs hematopoietic stem and progenitor cells quiescence and function. Exp Cell Res 2013, 319(17):2739-2746.

　　12.Gao K*, Li X, Zhang L, Bai L, Dong W, Shi G, Xia X, Wu L: Transgenic expression of IL-33 activates CD8(+) T cells and NK cells and inhibits tumor growth and metastasis in mice. Cancer Lett 2013, 335(2):463-471.

　　13.Bai L*, Deng X, Li Q, Wang M, An W, Deli A, Gao Z, Xie Y, Dai Y, Cong YS: Down-regulation of the cavin family proteins in breast cancer. J Cell Biochem 2012, 113(1):322-328.

　　14.Zhu B*, Deng X, Sun Y, Bai L, Xiahou Z, Cong Y, Xu X: Nampt is involved in DNA double-strand break repair. Chin J Cancer 2012, 31(8):392-398.

　　15.Bai L*, Deng X, Li J, Wang M, Li Q, An W, A D, Cong YS: Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1. Cell Res 2011, 21(7):1088-1101.

　　16.Yang K*, Zheng D, Deng X, Bai L, Xu Y, Cong YS: Lysophosphatidic acid activates telomerase in ovarian cancer cells through hypoxia-inducible factor-1alpha and the PI3K pathway. J Cell Biochem 2008, 105(5):1194-1201.