2022年01月27日 星期四  您是第1873707位访客
首页 > 人才队伍 > 研究员> 详情
鲍琳琳

鲍琳琳

姓名:鲍琳琳

学科:实验动物学

电话:010-67761941

邮件:bllmsl@aliyun.com

地址:北京市朝阳区潘家园南里5号,100021

  • 简历介绍
  • 研究领域
  • 社会任职
  • 获奖及荣誉
  • 承担科研项目情况
  • 代表论著

鲍琳琳,女,博士,研究员,博士生导师,法国巴黎第五大学癌症中心访问学者。主要从事新发再发感染性疾病动物模型应急研制和比较医学研究。新冠疫情攻关项目中研制新冠病毒小鼠和恒河猴模型;完成国家疫苗专班5条技术路线疫苗评价工作,其中3种疫苗进入3期临床。主持国家十一五、十二五和十三五科技重大专项子课题或子任务、北京市应急课题、中医行业基金等国家及省部级课题等共计十余项。以第一作者或通讯作者在Nature, Science, Cell, Nat Commun, JV和JID等期刊上发表SCI论文20篇,主编或参编著作5本。

感染性疾病动物模型研制,新发传染病病原传播力预警,新发和再发传染病发病机制研究,传染病疫苗、抗体和药物有效性和机制研究。

兼任中国实验动物学会动物实验生物安全专业委员会常务委员/秘书长、《中国实验动物学报》和《中国比较医学杂志》编委等职。

2011年,甲型流感病毒感染动物模型的建立及应用,北京市科技进步三等奖(2/11)

2015年,重大传染病动物模型资源库的建立及应用,教育部,科技进步奖,二等奖(3/16)

2018年,人类重大传染病动物模型体系的建立及应用, 中华医学会,医学科学技术奖,二等奖(4/10)

2019年,人类重大传染病动物模型体系的建立及应用, 国家科学技术进步奖,二等奖(3/10)

2018年,被评为中国医学科院医学实验动物研究所比较医学创新人才

获得2020年抗击新冠肺炎疫情全国三八红旗手称号。

  目前主要承担十三五传染病重大专子任务,药物、疫苗和抗体的动物模型评价能力优化和升级;重点研发项目子任务,重大突发动物源性人兽共患病病原感染与传播的适应性进化机制。

1.Linlin Bao, Wei Deng, Baoying Huang, Hong Gao, Jiangning Liu, Lili Ren, Qiang Wei, Pin Yu, Yanfeng Xu, Feifei Qi, Yajin Qu, Fengdi Li, Qi Lv, Wenling Wang , Jing Xue, Shuran Gong, Mingya Liu, Guanpeng Wang, Shunyi Wang, Zhiqi Song, Linna Zhao, Peipei Liu, Li Zhao , Fei Ye , Huijuan Wang , Weimin Zhou , Na Zhu , Wei Zhen , Haisheng Yu, Xiaojuan Zhang, Li Guo , Lan Chen , Conghui Wang , Ying Wang , Xinming Wang , Yan Xiao, Qiangming Sun , Hongqi Liu , Fanli Zhu , Chunxia Ma , Lingmei Yan , Mengli Yang , Jun Han , Wenbo Xu , Wenjie Tan , Xiaozhong Peng , Qi Jin , Guizhen Wu  & Chuan Qin . 2020. The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. NATURE , 583(7818):830-833. 2020:1-6.(IF:42.778)

2.Wei Deng , Linlin Bao , Jiangning Liu ,Chong Xiao , Jiayi Liu, Jing Xue , Qi Lv , Feifei Qi , Hong Gao , Pin Yu , Yanfeng Xu , Yajin Qu , Fengdi Li , Zhiguang Xiang, Haisheng Yu , Shuran Gong , Mingya Liu , Guanpeng Wang , Shunyi Wang , Zhiqi Song , Ying Liu , Wenjie Zhao , Yunlin Han , Linna Zhao , Xing Liu , Qiang Wei , Chuan Qin . 2020. Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques. SCIENCE,369(6505):818-823.(IF:41.845)
3.Yunlong Cao, Bin Su, Xianghua Guo, Wenjie Sun, Yongqiang Deng, Linlin Bao, Qinyu Zhu,Xu Zhang,Yinghui Zheng, Chenyang Geng, Xiaoran Chai, Runsheng He, Xiaofeng Li, Qi Lv, Hua Zhu, Wei Deng,Yanfeng Xu,Yanjun Wang, Luxin Qiao, Yafang Tan, Liyang Song,Guopeng Wang, Xiaoxia Du,Ning Gao,Jiangning Liu, Junyu Xiao, Xiao-dong Su, Zongmin Du, Yingmei Feng, Chuan Qin,Chengfeng Qin,Ronghua Jin, and X. Sunney Xie.2020. Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells. CELL,182(1):73-84.e16.(IF:38.637)
4.Qiang Gao , Linlin Bao , Haiyan Mao , Lin Wang, Kangwei Xu , Minnan Yang , Yajing Li , Ling Zhu , Nan Wang , Zhe Lv , Hong Gao , Xiaoqin Ge , Biao Kan , Yaling Hu , Jiangning Liu , Fang Cai , Deyu Jiang , Yanhui Yin , Chengfeng Qin , Jing Li , Xuejie Gong , Xiuyu Lou , Wen Shi , Dongdong Wu , Hengming Zhang , Lang Zhu , Wei Deng , Yurong Li , Jinxing Lu , Changgui Li , Xiangxi Wang , Weidong Yin , Yanjun Zhang , Chuan Qin .2020. Development of an inactivated vaccine candidate for SARS-CoV-2. SCIENCE. 369(6499):77-81. (IF:41.845)
5.Jingyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi, Linlin Bao, Fei Mo,Xue Li, Yong Huang, Weiqi Hong, Yun Yang, Yuan Zhao, Fei Ye, Sheng Lin, Wei Deng,Hua Chen, Hong Lei, Ziqi Zhang, Min Luo, Hong Gao, Yue Zheng, Yanqiu Gong, Xiaohua Jiang,Yanfeng Xu, Qi Lv, Dan Li, Manni Wang, Fengdi Li, Shunyi Wang, Guanpeng Wang, Pin Yu,Yajin Qu, Li Yang, Hongxin Deng, Aiping Tong, Jiong Li, Zhenling Wang, Jinliang Yang,Guobo Shen, Zhiwei Zhao, Yuhua Li, Jingwen Luo, Hongqi Liu, Wenhai Yu, Mengli Yang,Jingwen Xu, Junbin Wang, Haiyan Li, Haixuan Wang, Dexuan Kuang, Panpan Lin,Zhengtao Hu, Wei Guo, Wei Cheng, Yanlin He, Xiangrong Song, Chong Chen, Zhihong Xue,Shaohua Yao, Lu Chen, Xuelei Ma, Siyuan Chen, Maling Gou, Weijin Huang, Youchun Wang,Changfa Fan, Zhixin Tian, Ming Shi, Fu-Sheng Wang, Lunzhi Dai, Min Wu, Gen Li,Guangyu Wang, Yong Peng, Zhiyong Qian, Canhua Huang, Johnson Yiu-Nam Lau,Zhenglin Yang, Yuquan Wei, Xiaobo Cen, Xiaozhong Peng, Chuan Qin, Kang Zhang,Guangwen Lu & Xiawei Wei.2020. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity. NATURE.(IF:42.778)
6.Wei Deng, Linlin Bao, Hong Gao, Zhiguang Xiang, Yajin Qu, Zhiqi Song, Shuran Gong , Jiayi Liu, Jiangning Liu , Pin Yu , Feifei Qi , Yanfeng Xu , Fengli Li , Chong Xiao , Qi Lv , Jing Xue , Qiang Wei , Mingya Liu , Guanpeng Wang , Shunyi Wang , Haisheng Yu , Ting Chen , Xing Liu , Wenjie Zhao , Yunlin Han1 & Chuan Qin.2020.Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques. Nat Commun.11(1):4400. (IF:12.121)
7.Wei Deng , Yanfeng Xu , Qi Kong , Jing Xue , Pin YuJiangning LiuQi Lv , Fengdi Li , Qiang Wei , Linlin Bao.2020. Therapeutic efficacy of Pudilan Xiaoyan Oral Liquid (PDL) for COVID-19 in vitro and in vivo. Signal Transduct Target Ther. 5(1):66. (IF:13.493)
8.Linlin Bao, Hong Gao,  Wei Deng,  Qi Lv,  Haisheng Yu,  Mingya Liu,  Pin Yu, Jiangning Liu, Yajin Qu, Shuran Gong, Kaili Lin, Feifei Qi, Yanfeng Xu, Fengli Li, Chong Xiao, Jing Xue, Zhiqi Song, Zhiguang Xiang, Guanpeng Wang, Shunyi Wang, Xing Liu, Wenjie Zhao, Yunlin Han, Qiang Wei, and Chuan Qin.2020. Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice. J Infect Dis. 222(4):551-555. (IF:5.022)
9.Linlin Bao, Yuhai Bi, Gary Wong, Wenbao Qi, Fengdi Li, Qi Lv, Liang Wang, Fei Liu, Yang Yang, Cheng Zhang, William J. Liu, Chuansong Quan, Weixin Jia, Yingxia Liu, Wenjun Liu, Ming Liao, George F. Gao & Chuan Qin.2019.Diverse biological characteristics and varied virulence of H7N9 from Wave 5. Emerg Microbes Infect.8(1):94-102. (IF:5.776)
10.Xuehong Jia, Bo Liu, Linlin Bao, Qi Lv , Fengdi Li , Hui Li , Yunqing An , Xulong Zhang , Bin Cao, Chen Wang.2018. Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration. PLoS Pathog. 14(11):e1007428. (IF:6.218)
11.Yao Deng , Jiaming Lan, Linlin Bao, Baoying Huang , Fei Ye , Yingzhu Chen , Yanfeng Yao , Wenling Wang , Chuan Qin and Wenjie Tan.2018. Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus. Emerg Microbes Infect.7(1):60.(IF:5.776)
12.Zhe Chen, Linlin Bao, Cong Chen, Tingting Zou, Ying Xue, Fengdi Li, Qi Lv, Songzhi Gu,  Xiaopan Gao, Sheng Cui,  Jianmin Wang,  Chuan Qin,and Qi Jin. 2017. Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset. J Infect Dis.215(12):1807-1815. (IF:5.022)
13.Zhe Chen, Jianmin Wang, Linlin Bao, Li Guo, Weijia Zhang, Ying Xue, Hongli Zhou, Yan Xiao,Jianwei Wang, Fan Wu, Ying Deng, Chuan Qin, Qi Jin. 2015. Human monoclonal antibodies targeting the haemagglutinin glycoprotein can neutralize H7N9 influenza virus[J]. Nature Communications,  6:6714.(IF:12.121)
14.Chunxue Xue, Mingjie Wen, Linlin Bao, Hui Li, Fengdi Li, Meng Liu, Qi Lv, Yunqing An, Xulong Zhang, Bin Cao. 2017. Vγ4+γδT Cells Aggravate Severe H1N1 Influenza Virus Infection-Induced Acute Pulmonary Immunopathological Injury via Secreting Interleukin-17A. Front Immunol, 8: 1054.(IF:5.085)
15. Feifei Qi, Mingya Liu, Fengdi Li, Qi Lv, Guanpeng Wang, Shuran Gong, Shunyi Wang, Yanfeng Xu, Linlin Bao, Chuan Qin. 2019. Interleukin-37 Ameliorates Influenza Pneumonia by Attenuating Macrophage Cytokine Production in a MAPK-Dependent Manner. Front Microbiol, 10:2482.(IF:4.235)
16.Shuran Gong, Feifei Qi, Fengdi Li, Qi Lv, Guanpeng Wang, Shunyi Wang, Jing Jiang, Lin Wang, Linlin Bao, Chuan Qin. 2019. Human-Derived A/Guangdong/Th005/2017 (H7N9) Exhibits Extremely High Replication in the Lungs of Ferrets and Is Highly Pathogenic in Chickens. Viruses, 11(6): 494.(IF:3.816)
17.Jianmin Wang, Zhe Chen, Linlin Bao, Weijia Zhang, Ying Xue, XingHuo Pang, Xi Zhang, Chuan Qin, Qi Jina. 2015. Characterization of Two Human Monoclonal Antibodies NeutralizingInfluenza A H7N9 Viruses. Journal of virology, 89 (17).(IF:4.501)
 

参编著作:

1、《我们身边的人兽共患病》,科学普及出版社,2016年4月,副主编 

2、《实验动物学》,中国协和医科大学出版社,2016年1月,参编  

3、《常见和新发传染病动物模型》,中国协和医科大学出版社,2011年,参编