Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2209-11. doi: 10.1016/j.bmcl.2012.01.102. Epub 2012 Feb 2.

Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo.

Yang Y, Zhang L, Fan X, Qin C, Liu J.

Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, PUMC, Beijing, China.

Abstract

Human enterovirus 71 infection causes hand, foot and mouth disease in children under 6 years of age and has caused mortalities in large-scale outbreaks in the Asia-Pacific region. No effective vaccine or antiviral drugs currently exist against enterovirus 71 in the clinic. In this study, we investigated the antiviral effect of geraniin on enterovirus 71 both in vitro and in vivo. The results showed that geraniin effectively inhibited virus replication in rhabdomyosarcoma cells with an IC(50) of 10 μg/ml. Moreover, geraniin treatment of mice that were challenged with a lethal dose of enterovirus 71 resulted in a reduction of mortality, relieved clinical symptoms, and inhibited virus replication in muscle tissues. The results suggest that geraniin may be used as a potential drug for anti-enterovirus 71.

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