Respiratory Virus Research Group

Bao Linlin PI
Qi Feifei	Liu Liya postgraduate

Contact Information: 010-67761942

Scientific research achievements:

The research group has played an important role in many influenza outbreaks. The rapid establishment of mouse and ferret-infected animal models during the 2009 H1N1 outbreak not only provided information on the virulence and transmissibility of the new influenza virus, but also provided an effective reserve list of drugs and vaccines, on this basis, which provided strong data support for the national prevention and control measures. Under the situation of national drug shortage, animal model was applied to screen Chinese patent medicine for market sale, which provided drug reserve for the smooth progress of national 60th Anniversary celebration. It provides the effectiveness evaluation for Beijing's first independent intellectual property rights Jinhuaqinggan granules, which has obtained the national new drug certificate and marketing license. After the outbreak of H7N9 avian influenza in 2013, the animal model of mouse and ferret infection was rapidly established, and standardized evaluation techniques and indicators were established, which could be compared with the international influenza laboratory. The establishment of this model provided strong support for the follow-up evaluation of drugs, vaccines and antibodies. The ferret model was used to evaluate the safety of the first attenuated strain vaccine with independent intellectual property rights in China. The therapeutic and preventive effects of humanized H7N9 monoclonal antibody on H7N9 virus were evaluated by using the mouse model. The biological half-time of the antibody was further evaluated in a mouse model, and the escape strains under immune pressure were analyzed after the antibody was applied. To provide data support for antibody development to translate into clinical applications, the results were published with Nat Commun in 2015. With this publication, our cooperation with many research institutes and companies in China.

Representative papers:

　　1. Xu L, Bao L, Li F, Gu S, Lv Q, Yuan J, Xu Y, Zhu H, Deng W, Li Y, Yao Y, Yu P, Gao Z, Qin C. Combinations of Oseltamivir and Fibrates Prolong the Mean Survival Time of Mice Infected with the Lethal H7N9 Influenza Virus. J Gen Virol. 2015, 96:46-51

　　2. Xu L, Bao L, Deng W, Dong L, Zhu H, Chen T, Lv Q, Li F, Yuan J, Xiang Z, Gao K, Xu Y, Huang L, Li Y, Liu J, Yao Y, Yu P, Li X, Huang W, Zhao X, Lan Y, Guo J, Yong W, Wei Q, Chen H, Zhang L, Qin C. The Novel Avian-Origin Human A (H7N9) Influenza Virus Could be Transmitted between Ferrets via Respiratory Droplets. Journal of Infectious Disease. 2014, 15; 209(4):551-6

　　3. Xu L, Bao L, Deng W, Zhu H, Li F, Chen T, Lv Q, Yuan J, Xu Y, Li Y, Yao Y, Gu S, Yu P, Chen H, Qin C. Rapid adaptation of avian H7N9 virus in pigs. Virology. 2014, 452-453:231-6

　　4. Bao L, Xu L, Zhu H, Deng W, Chen T, Lv Q, Li F, Yuan J, Xu Y, Huang L, Li Y, Liu J, Yao Y, Yu P, Chen H, Qin C. Transmission of H7N9 influenza virus in mice by different infective routes. Virology Journal, 2014, 11:185.

　　5. Xu L, Bao L, Deng W, Zhu H, Chen T, Lv Q, Li F, Yuan J, Xiang Z, Gao K, Xu Y, Huang L, Li Y, Liu J, Yao Y, Yu P, Yong W, Wei Q, Zhang L, Qin C. The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus. Virology Journal, 2013, 10:253.

　　6. Xu L, Bao L, Yuan J, Li F, Lv Q, Deng W, Xu Y, Yao Y, Yu P, Chen H, Yuen KY, Qin C. Antigenicity and transmissibility of a new clade 2.3.2.1 avian influenza H5N1 virus. Journal of General Virology. 2013, 94, 2616–2626

　　7. Jianmin Wang, Zhe Chen, Linlin Bao, Weijia Zhang,Ying Xue,XingHuo Pang, Xi Zhang,Chuan Qin,Qi Jina. Characterization of Two Human Monoclonal Antibodies Neutralizing Influenza A H7N9 Viruses. JVI, 2015,9115-9118.