Cardiovascular Disease Research Group
Overview:
This research group mainly researches the pathogenesis of cardiovascular diseases and related animal models, including the mechanism of salt metabolism regulating blood pressure and developing target organ injury through sodium absorption and excretion as well as chronic inflammation. The pathogenesis of cardiovascular diseases such as atherosclerosis, cardiomyopathy and large hemangioma caused by inflammatory reaction and metabolic disorder of the body; They carry out the production of animal models of genetic engineering, chemical/physical/food induction, surgical operation, hypertension, cardiomyopathy, hemangioma and other mice and determine their basic physiological functions. There are more than 30 animal models of dopamine receptor, gastrin receptor, inflammatory factor, sodium/potassium ion channel, metabolic regulator and other related genetic engineering, and more than 10 non-genetic engineering model preparation techniques.
At present, the tasks undertaken or completed include: national "863", National Natural Science Foundation general project, Youth Fund project, Ministry of Health industry fund, major special projects of science and technology of National "The 11th Five-Year Plan" and "The 12th Five-Year Plan", medical and health science and technology innovation project of Chinese Academy of Medical Sciences and many other scientific research subjects.
Research directions:
The research group is mainly engaged in the research on the pathogenesis of hypertension, atherosclerosis, cardiomyopathy, large hemangioma and other related animal models.
Staff Composition:
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Research Leader: Yang Zhiwei Researcher |
Assistant researcher: |
Assistant researcher：
Dr Wu Xianxian |
Technologist-in-charge: |
Contact Information: 010-67776809
Scientific research Achievements:
More than 40 papers have been published in Chinese and foreign journals such as Hypertension and Am J Physiol.
1. Nicotine promotes atherosclerosis via ROSNLRP3-mediated endothelial cell pyroptosis. Cell Death and Disease。2018; 9: 171.
2. The development of salt-sensitive hypertension regulated by PSGL-1 gene in mice. Cell Biosci. 2018; 8: 20.
3. Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROSover-generation by NADPH oxidase activation and Nrf2 degradation. Redox Biology. 2018; 19: 134–46.
4．Gastrin stimulates renal dopamine production by increasing the renal tubular uptake of L-DOPA.Am J Physiol Endocrinol Metab. 2017; 312: E1–E10.
5. Regulation of blood pressure, oxidative stress and AT1R by high salt diet in mutant human dopamine D5 receptor transgenic mice. Hypertension Research. 2015; 38: 394–9.
6. Single-Nucleotide Polymorphisms of the Dopamine D2 Receptor Increase Inflammation and Fibrosis in Human Renal Proximal Tubule Cells. Hypertension. 2014; 63: e74-e80.
7. The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion. PLOS ONE. 2016.
8. Basal and postprandial serum levels of gastrin in normotensive and hypertensive adults.Clin Exp Hypertens. 2013; 35(1):74-8.
9. Regulation of blood pressure, oxidative stress and AT1R by high salt diet in mutant human dopamine D5 receptor transgenic mice. Hypertens Res. 2015; 38(6): 394-9
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