Radiological Diseases Research Group

Research Directions:

Mice and cell damage models were established to explore the cellular and molecular mechanism of radiation and chemotherapy on normal tissues, especially hematopoietic stem cells, so as to provide experimental basis for the development of protective measures against tissue damage. On this basis, other tissue adult stem cell injury and intervention studies were discussed.

Staff Composition:

Meng Aimin, researcher, group leader, she is the researcher and doctoral supervisor of Institute of Laboratory Animal Sciences of Chinese Academy of Medical Sciences, member of Radiology Toxicology Committee of Chinese Toxicology Society, member of Biochemical and Molecular Pharmacology Professional Committee of Chinese Pharmacology Society and member of academic Committee of Chinese Academy of Medical Sciences.

Guan Bowen

Technician, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences

Lu Yanhua

Graduate student of Institute of  Laboratory Animal Sciences, Chinese Academy of Medical Sciences

Contact Information: 010-67766299

Scientific Research Achievements:

1) The radiation injury model was established, including whole-body irradiation, local irradiation inducing hematopoietic immunity, intestinal, brain, lung and skin injury models, to provide a basis for the study of radiation injury mechanism and intervention; The article was published in Cancer Res; Blood magazines;

Radiation damage to the hematopoietic system

radiation injury of intestine
  

Skin and hair damage caused by local irradiation

2) Research on tissue stem cell damage mechanism and intervention mechanism to explore the molecular mechanism and intervention of radiation on tissue stem cell damage, so as to provide a research basis for the prevention and treatment of toxic and side effects of radiotherapy and chemotherapy; Articles have been published in Free Radic Biol Med, Nature Med, Int J Radiat Oncol Biol Phys, etc. Obtained 4 patents.

 Research on hematopoietic stem cell injury and its intervention mechanism