Organ Humanization Research Group

Overview:

Using genetic engineering and somatic cell cloning techniques, the organ humanization research group established and analyzed the miniature pig model that could be used for organ transplantation, so as to solve the possible immune rejection reaction, coagulation disorder inflammatory reaction and potential biological safety problems caused by donor animals. Based on the existing models, the neoantigens causing immune rejection after xenotransplantation were screened to optimize the gene modification of donor animals.

Research Direction:

Establishment and preclinical application of xenotransplantation miniature pig animal model;

Construction of a genetically engineered miniature pig disease model.

Staff Composition:

Lu Tianyu Doctor		Yang Bochao Doctor
Wang Ruolin techician	Xu Yaxin techician	Yu Jianan

Scientific research achievements:

A miniature pig model was established for the removal of α-Gal antigen from pig cell surface.