PDX Model Transformation Research Group

Overview:

The mission of the PDX model transformation research group is the establishment and preclinical application of the PDX (human tumor xenotransplantation) model. At present, the research group has 3 staff members (1 deputy senior, 1 intermediate and 1 junior). Research group has undertaken many research projects, including the National Natural Science Foundation of China, 863 major special projects, Natural Science Foundation of Beijing, Chinese Academy of Medical Sciences, Medicine and Health Science and Technology Innovation Project, basic scientific research business expenses of Central Public Welfare Scientific Research Institute. Research results are published in Molecular Immunology, Cellular Signalling, FEBS Letters and the like. They applied 2 patents, one of which has been authorized.

Research Direction:

The main research areas of the research group include: 1. Establishment of PDX model and preclinical application: (1) Establishment of PDX model for various tumors (esophageal cancer, gastric cancer, colorectal cancer, liver cancer, hypopharyngeal cancer, meningioma, etc.); 2. (2) Establish tumor PDX resource library; (3) Screening of sensitive chemotherapy drugs and individualized cancer treatment research.

Staff Composition:

Dr Zhan Xiangwen Assistant Researcher	Zhu Ruimin Technician

Scientific and research achievements:

　　1.J Guo, X Qiu, L Zhang, R Wei*. Smurf1 regulates macrophage proliferation, apoptosis and migration via JNK and p38 MAPK signaling pathways. Mol. Immunol. 2018, 97: 20-26.

　　2.R Wei, B Li, J Guo, M Li, R Zhu, X Yang, R Gao. Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition. Cell. Signal. 2017, 38:60-66.

　　3.R Wei, J Guo, M Li, X Yang, R Zhu, H Huang, K Li, L Zhang, Ran Gao. Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation. FEBS Lett. 2017, 591(8):1150-1158.

　　4.R Wei, X Qiu, S Wang, Y Wang, Y Fu, G Xing, F He, L Zhang. NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling. Cell. Signal. 2015, 27(3):578-86.

　　5.H Huang, Y Han, X Yang, R Zhu, J Hu, X Zhang, R Wei, K Li, R Gao. HNRNPK inhibits gastric cancer cell proliferation through p53/p21/CCND1 pathway. Oncotarget. 2017, 10.18632/oncotarget.21873.

　　6.X Qiu, R Wei, Y Li, Q Zhu, C Xiong, Y Chen, Y Zhang, K Lu, F He, L Zhang. NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Oncotarget 2016, 7(21): 31440-53

　　7.Shu J, Liu C, Wei R, Xie P, He S, Zhang L. Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation. Biochem. Biophys. Res. Commun. 2016, 474(1):51-6.

　　8.J Nie*, L Liu*, G Xing*, M Zhang*, R Wei, M Guo, X Li, P Xie, L Li, F He, W Han, L Zhang. CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation. Oncogene 2014, 33(28):3677-87.

　　9.L Lu, S Hu, R Wei, X Qiu, K Lu, Y Fu, H Li, G Xing, D Li, R Peng, F He, L Zhang. HECT Type Ubiquitin Ligase NEDL2 is degraded by APC/C-Cdh1 and its Tight Regulation Maintains the Metaphase to Anaphase Transition. J. Biol. Chem. 2013, 288(50): 35637-50.

　　10.L Zhang*, Y Wang*, F Xiao, S Wang, G Xing, Y Li, X Yin, K Lu, R Wei, J Fan, Y Chen, T Li, P Xie, L Yuan, L Song, L Ma, L Ding, F He, L Zhang. CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation. Cell Res. 2014, 24(6):742-61.

　　11.Zhan X, Yang J, Mao Z and Yu W. PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast. Biochem. Biophys. Res. Commun. 2018, 501(3): 779-785