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Combinations of oseltamivir and fibrates prolong the mean survival time of mice infected with the lethal H7N9 influenza virus
The outbreak of human infections caused by the novel avian-origin H7N9 influenza viruses in China since March 2013 underscores the urgent need to find an effective treatment strategy against H7N9 infection in humans. In this study,
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The distribution of transplanted human mesenchymal stem cells in the CNS of young Macaca fascicularis
Mesenchymal stem cell (MSC)-based therapies have generated much hope and promise as a potential source of cells for cell-based therapeutic strategies in pediatric degenerative diseases. However, the distribution and migratory routes of MSCs are unknown. Here,
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Valproate improves memory deficits in an Alzheimer's disease mouse model: investigation of possible mechanisms of action
(AD) is a very common progressive neurodegenerative disorder affecting the learning and memory abilities in the brain
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Tubastatin A/ACY-1215 improves cognition in Alzheimer's disease transgenic mice
Histone deacetylase 6 (HDAC6) is currently being discussed as a promising therapeutic target for the treatment of Alzheimer's disease (AD). Mounting evidence indicates that increased HDAC6 expression may contributeto AD-associated neurodegeneration,
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Histopathological features and distribution of EV71 antigens and SCARB2 in human fatal cases and a mouse model of enterovirus 71 infection
Enterovirus 71 (EV71) is a neurotropic pathogen that causes hand, foot, and mouth disease. While infection is usually self-limiting, a minority of patients infected with EV71 develop severe neurological complications. In humans,