Group of Cancer Research
Introduction:
The tumor research laboratory was established in 2014, with an area of 100 m2. The lab was equipped with different kinds of equipment for basic cellular and molecular biology research, such as inverted fluorescence microscope, biosafety cabinet, cell incubator, analytical balance, PCR device, ultrasonic crushing instrument, etc. Our group also makes full use of resources from the institute that is equipped with flow cytometry, laser confocal microscope and other platform for imaging. This including small animal PET/CT, 7T small animal magnetic resonance imaging (MRI), small animal ultrasonic imaging , Caliper IVIS Lumina II, two-photon laser scanning microscopy, etc. All of these equipment and platform meet the requirements of experiments not only at molecular level but also in living animals.
Research Interests:
Our interest covers the establishment of animal models for tumor research, and initiates comparative medical research using the established animal models. The research group makes full use of the resources and platform from the institute to carry out original, pioneering and systematic research on the establishment of tumor animal model. In the research process, the research group emphasizes mutual assistance and resource sharing, advocates the integration of cross-disciplines, uses tumor animal model to reveal the mechanism of tumor genesis and development, and provides powerful tools for tumor treatment and anticancer drug research.
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Group Leader: |
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Gao Ran Associate Researcher |
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Group Members: |
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Zhang Wenlong Assistant Researcher
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Li Mengyuan Technologist-in-charge |
Yang Xingjiu Technologist |
Contact Information: 010-67779532
Achievements:
The research group has established more than 300 types of human tumor xenotransplantation model (PDX), subcutaneous/orthotopic tumor mouse model, and can use tumor animal model to screen anticancer drugs and evaluate their pharmacodynamics, as well as carry out relevant cell biology and molecular biology tests.
Representativ publications：
1.Cao L, Huang T, Chen X, Li W, Yang X, Zhang W, Li M, Gao R*. Uncovering the interplay between pH receptors and immune cells: Potential drug targets (Review). Oncol Rep. 2021 Oct;46(4):228. doi: 10.3892/or.2021.8179. Epub 2021 Sep 3.
2.Cao L, Li W, Yang X, Zhang W, Li M, Zhang H, Qin C, Chen X*, Gao R*. Inhibition of host Ogr1 enhances effector CD8+ T-cell function by modulating acidic microenvironment. Cancer Gene Ther. 2021 Jun 22. doi: 10.1038/s41417-021-00354-0. Epub ahead of print.
3.Li W, Cao L, Li M, Yang X, Zhang W, Song Z, Wang X, Zhang L, Morahan G, Qin C*, Gao R*. Novel spontaneous myelodysplastic syndrome mouse model. Animal Model Exp Med. 2021 May 14;4(2):169-180.
4.Li W, Li M, Yang X, Zhang W, Cao L, Gao R*. Summary of animal models of myelodysplastic syndrome. Animal Model Exp Med. 2021 Feb 3;4(1):71-76.
5.Zhang G, Yang X, Gao R*. Research progress on the structure and function of endomucin. Animal Model Exp Med. 2021 Jan 15;3(4):325-329. doi: 10.1002/ame2.12142.
6.Liu H, Chen X, Yang X, Li M, Zhang W, Zhang G, Zhan X, Cao L, Li W, Huang Z*, Gao R*. Involvement of the Wnt/β-Catenin signaling pathway in the heterogenous nuclear ribonucleoprotein K-driven inhibition of proliferation and migration in head and neck squamous cell carcinoma. Oncol Lett. 2020 Dec;20(6):394.
7.Shi X*, Gao K, Xiong S, Gao R*. Multifunctional Transferrin Encapsulated GdF3 Nanoparticles for Sentinel Lymph Node and Tumor Imaging. Bioconjug Chem. 2020 Nov 18;31(11):2576-2584.
8.Zhang W, Han Y, Li W, Cao L, Yan L, Qin C*, Gao R*. Clinical data analysis reveals the role of OGR1 (GPR68) in head and neck squamous cancer. Animal Model Exp Med. 2020 Mar 18;3(1):55-61.
9.Li M, Zhang W, Yang X, Liu H, Cao L, Li W, Wang L, Zhang G, Gao R*. Downregulation of HNRNPK in human cancer cells inhibits lung metastasis. Animal Model Exp Med. 2019 Nov 21;2(4):291-296.
10.Shi X, Gao K, Gao R*. 64Cu-Based Pretargeted Immuno-Positron Emission Tomography and Near-Infrared Fluorescence Imaging of the Vascular Endothelial Growth Factor. ACS Omega 2019, 4, 5310-5316.
11.Sun S, Li K, Lei Z, Xiao L, Gao R*, Zhang Z*. Immunomodulatory activity of polysaccharide from Helicteres angustifolia L. on 4T1 tumor-bearing mice. Biomed Pharmacother. 2018 May;101:881-888.
12.Shi X, Gao K, Huang H, Gao R*. Pretargeted Immuno-PET Based on Bioorthogonal Chemistry for Imaging EGFR Positive Colorectal Cancer. Bioconjug Chem. 2018 Feb 21;29(2):250-254.
13.Huang H, Han Y, Yang X, Li M, Zhu R, Hu J, Zhang X, Wei R, Li K, Gao R*. HNRNPK inhibits gastric cancer cell proliferation through p53/p21/CCND1 pathway. Oncotarget. 2017 Oct 17;8(61):103364-103374.
14.Wei R*, Li B, Guo J, Li M, Zhu R, Yang X, Gao R*. Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition. Cell Signal. 2017 Oct;38:60-66.
15.Wei R*, Guo J, Li M, Yang X, Zhu R, Huang H, Li K, Zhang L, Gao R*. Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation. FEBS Lett. 2017 Apr;591(8):1150-1158
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