Developmental Disorders Research Group
Overview:
The Developmental Disease Research Group of Center for Comparative Medicine was established in 2011, led by researcher Yong Weidong, research group leader. He received his bachelor degree from Lanzhou University in 1990, his master degree from Inner Mongolia University in 1996, and his doctor degree from Chinese Academy of Sciences in 1999. From 2000 to 2011, he was a postdoctoral, research assistant and research assistant professor at Purdue University and Indiana University School of Medicine. In 2011, he worked in Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences as distinguished professor and scholar of Peking Union Medical College. He mainly engaged in the creation of laboratory animal models and developmental biology research. For the first time, the relationship between hormone receptor cochaperone and hypospadias in male mice was found, and further studies showed that it was related to the transcriptional activity of estrogen and androgen receptors. In addition, through the study of protein phosphatase 5, it is found that the cancer suppressor gene p53 and PP5 can directly interact in vivo, and there is a mutual regulatory relationship between the two at the protein and transcription level, which is a great promotion for the study of the cancer suppressor gene p53. He has published more than 30 SCI papers. He has undertaken 863, 973, major special projects of the Ministry of Science and Technology, National Natural Science Foundation of China and other national projects. There are 1 researcher, 2 technicians and 1 graduate student in the research group.
Research Directions:
They study the relationship between hormone receptor-related proteins and development and disease, and the role and mechanisms of these genes in development and disease are revealed at the entirety, tissue, cellular, and molecular levels using a series of animal models created related to them:
1. The role of glucocorticoid-receptor-related (GR) protein FKBP51 in liver glucose and lipid metabolism and liver fibrosis;
2. The role of androgen receptor (AR) and estrogen receptor (ER) in male and female reproductive development and behavior;
3. The relationship between protein phosphatase 5 (PP5) and fat metabolism, bone development and tumorigenesis.
4. Various cell and mouse models were created by using transgenic technology, ES cell homologous recombination, CRISP/Cas9 and other technologies.
Staff Composition:
Group leader: Yong Weidong, Distinguished Professor of Institute and Peking Union Medical College Hospital，undertaking the editorial board member of "Journal of Experimental Animals", "Journal of Comparative Medicine", "Animal Models and Experimental Medicine" ; Member of the first Union of Young Scientists League
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Group Member: Deng Ran |
Group Member: Wang Chao |
Contact Information: 010-67762060
Scientific Research Achievements:
1. Bin Qiu, Yuxue Xu, Lingling Zhang, Jun Wang, Ming Liu, Chao Wang, Ran Deng, Kent Williams, Robert Stewart, Zhongwen Xie, Tiebing Liang*, Weidong Yong*. Loss of FKBP5 plays a critical role in neuronal synaptic plasticity and depression-like behavior. Neuroscience. 2019 Jan 24.
2. Spence JP, Reiter JL, Qiu B, Gu H, Garcia DK, Zhang L, Graves T, Williams KE, Bice PJ, Zou Y, Lai Z, Yong W* and Liang T*. Estrogen-Dependent Upregulation of Adcyap1r1 Expression in Nucleus Accumbens Is Associated with Genetic Predisposition of Sex-Specific QTL for Alcohol Consumption on Rat Chromosome 4. Frontiers in Genetics. 2018 Dec 04 9:513. (Co-corresponding author)
3. Wang J, Shen T, Zhu W, Dou L, Gu H, Zhang L, Yang Z, Chen H, Zhou Q, Sánchez ER, Field LJ, Mayo LD, Xie Z, Xiao D, Lin X, Shou W*, Yong W*. Protein phosphatase 5 and the tumor suppressor P53 down-regulate each other’s activities in mice. J Biol Chem. 2018 Nov 23;293(47):18218-18229.
4. Wang J, Cao Y, Qiu B, Du J, Wang T, Wang C, Deng R, Shi X, Gao K, Xie Z*, Yong W*. Ablation of protein phosphatase 5 (PP5) leads to enhanced both bone and cartilage development in mice. Cell Death Dis. 2018 Feb 12;9(2):214.
5. Zhang L, Qiu B, Wang T, Wang J, Liu M, Xu Y, Wang C, Deng R, Williams K, Yang Z, Liang T, Yong W*. Loss of FKBP5 impedes adipocyte differentiation under both normoxia and hypoxic stress. Biochem Biophys Res Commun. 2017 Apr 15;485(4):761-767.
6. Stechschulte LA, Qiu B, Warrier M, Hinds TD Jr, Zhang M, Gu H, Xu Y, Khuder SS, Russo L, Najjar SM, Lecka-Czernik B, Yong W*, Sanchez ER*. FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone. Endocrinology. 2016 Oct;157(10):3888-3900 (Co-corresponding author)
7. Gu H, Cao Y, Qiu B, Zhou Z, Deng R, Chen Z, Li R, Li X, Wei Q, Xia X, Yong W*. Establishment and phenotypic analysis of an Mstn knockout rat. Biochem Biophys Res Commun. 2016 Aug 12;477(1):115-22.
8. Qiu B, Luczak SE, Wall TL, Kirchhoff AM, Xu Y, Eng MY, Stewart RB, Shou W, Boehm SL, Chester JA, Yong W*, Liang T*. The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans. Int J Mol Sci. 2016 Aug 5;17(8). (Co-corresponding author)
9. Qiu B, Bell RL, Cao Y, Zhang L, Stewart RB, Graves T, Lumeng L, Yong W*, Liang T*. Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. J Genet Genomics. 2016 Jul 20;43(7):421-30. (Co-corresponding author)
10. Zhang Y, Wang J, Liu J, Han J, Xiong S, Yong W, Zhao Z. Combination of ESI and MALDI mass spectrometry for qualitative, semi-quantitative and in situ analysis of gangliosides in brain. Sci Rep. 2016 May 4;6:25289.
11. Yong W, Spence JP, Eskay R, Fitz SD, Damadzic R, Lai D, Foroud T, Carr LG, Shekhar A, Chester JA, Heilig M, Liang T. Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-non preferring rats. Alcohol Clin Exp Res. 2014 May;38(5):1275-83.
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