Stem Cell Translational Medicine Research Group
Overview:
Our group focoses on the translational research into stem cell therapies, incuding Neurodegenerative disease, Hematological disease and cardiovascular diseases., We provides the animal models and the preclinical evaluation for the translational research of stem cell therapies. Our group has undertaken many research projects, including the Beijing Natural Science Foundation, National Science Foundation of China, CAMS Innovation Fund for Medical Sciences, The National Science Foundation for Young Scholars of China, New Teachers' Fund for Doctor Stations, Ministry of Education, etc.in the related papers are published on the academic journals such as Cell Research, Cell Death and Diseases, Experimental Cell Research and Journal of Cellular Biochemistry and etc.
The Research Interests:
(1) Banking of stem cell lines fromthe animal models of diseases for basic and translational research
(2) Preclinical Efficacy and Safety Evaluation of stem cell therapy in the animal models of diseasey.
(3) Research on the aging mechanism of stem cells.
Staff Composition:
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| Dr Bai Lin, Associate researcher |
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Shi Guiying |
Huang Yiying
Research intern |
Lie Xuepei
Assistant researcher |
Scientific Research Achievements:
(1) Banking of stem cell lines from the animal models of diseases for basic and translational research
(2) Improved cell therapy evaluation system of efficacy and safety for the Parkinson's disease based on differentiation animal models.
(3) Established genetically modified mice were used to understanding the gene function during aging will lend support to develop therapeutic approaches to slow down aging process and improve old organ functions
Research Grants:
Beijing Natural Science Foundation 2020.01-2022.12
National Science Foundation of China 2017.01 - 2020.12
CAMS Innovation Fund for Medical Sciences 2016.01-2020.12
The National Science Foundation for Young Scholars of China 2013.01-2015.12
New Teachers' Fund for Doctor Stations, Ministry of Education 2013.01-2015.12
List of Published Articles:
1.Lin Bai*, Guiying Shi, Yuanwu Ma, Li Zhang, Feifei Guan, Xu Zhang, Yanfeng Xu, Houzao Chen and Lianfeng Zhang: Paraoxonase 1 knockout rats have impaired T cell development at the CD4/CD8 double-negative to double-positive transition stage. Scientific Reports 8: 14457 (2018)
2.Li Q*, Bai L*, Shi G, Zhang L, Dai Y, Liu P, Cong YS, Wang M: Ptrf transgenic mice exhibit obesity and fatty liver. Clinical and experimental pharmacology & physiology 2018.
3.Ma Y*, Yu L, Zhang X, Xin C, Huang S, Bai L, Chen W, Gao R, Li J, Pan S, Qi X, Huang X, Zhang L: Highly efficient and precise base editing by engineered dCas9-guide tRNA adenosine deaminase in rats. Cell Discov, 2018 Jul 17.
4.Ma Y*, Yu L, Pan S, Gao S, Chen W, Zhang X, Dong W, Li J, Zhou R, Huang L, Han Y, Bai L, Zhang L, Zhang L. CRISPR/Cas9-mediated targeting of the Rosa26 locus produces Cre reporter rat strains for monitoring Cre-loxP-mediated lineage tracing. FEBS J. 2017 Oct;284(19):3262-3277.
5.Bai L*, Shi G, Yang Y, Chen W, Zhang L: Anti-Aging Effect of Siraitia grosuenoriiby Enhancement of Hematopoietic Stem Cell Function. Am J Chin Med 2016:1-13.
6.Bai L*, Shi G, Zhang L, Guan F, Ma Y, Li Q, Cong YS, Zhang L: Cav-1 deletion impaired hematopoietic stem cell function. Cell Death Dis 2014, 5:e1140.
7.Ma Y*, Zhang X, Shen B, Lu Y, Chen W, Ma J, Bai L, Huang X, Zhang L: Generating rats with conditional alleles using CRISPR/Cas9. Cell Res 2014, 24(1):122-125.
8.Li Q*, Bai L*, Liu N, Wang M, Liu JP, Liu P, Cong YS: Increased polymerase I and transcript release factor (Cavin-1) expression attenuates platelet-derived growth factor receptor signalling in senescent human fibroblasts. Clin Exp Pharmacol Physiol 2014, 41(3):169-173.
9.Yang Y*, Ma J, Xiu J, Bai L, Guan F, Zhang L, Liu J: Deferoxamine compensates for decreases in B cell counts and reduces mortality in enterovirus 71-infected mice. Mar Drugs 2014, 12(7):4086-4095.
10.Ma Y*, Ma J, Zhang X, Chen W, Yu L, Lu Y, Bai L, Shen B, Huang X, Zhang L: Generation of eGFP and Cre knockin rats by CRISPR/Cas9. FEBS J 2014, 281(17):3779-3790.
11.Bai L*, Shi G, Zhang X, Dong W, Zhang L: Transgenic expression of BRCA1 disturbs hematopoietic stem and progenitor cells quiescence and function. Exp Cell Res 2013, 319(17):2739-2746.
12.Gao K*, Li X, Zhang L, Bai L, Dong W, Shi G, Xia X, Wu L: Transgenic expression of IL-33 activates CD8(+) T cells and NK cells and inhibits tumor growth and metastasis in mice. Cancer Lett 2013, 335(2):463-471.
13.Bai L*, Deng X, Li Q, Wang M, An W, Deli A, Gao Z, Xie Y, Dai Y, Cong YS: Down-regulation of the cavin family proteins in breast cancer. J Cell Biochem 2012, 113(1):322-328.
14.Zhu B*, Deng X, Sun Y, Bai L, Xiahou Z, Cong Y, Xu X: Nampt is involved in DNA double-strand break repair. Chin J Cancer 2012, 31(8):392-398.
15.Bai L*, Deng X, Li J, Wang M, Li Q, An W, A D, Cong YS: Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1. Cell Res 2011, 21(7):1088-1101.
16.Yang K*, Zheng D, Deng X, Bai L, Xu Y, Cong YS: Lysophosphatidic acid activates telomerase in ovarian cancer cells through hypoxia-inducible factor-1alpha and the PI3K pathway. J Cell Biochem 2008, 105(5):1194-1201.
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